Philosophy in the 19th century experienced a ‘turn from idealism,’ when idealist philosophies were largely abandoned for materialist ones. Scientific naturalism is now considered by many analytic philosophers to be the new orthodoxy, largely in part due to the success of the scientific method. The New Atheists, such as Daniel Dennett and Richard Dawkins, claim it is Darwin in particular who deserves much of the credit for repudiating the traditional Mind-first world view. Some, like Alvin Plantinga and Michael Behe, maintain (...) the opposite, that evolution casts doubt on naturalism and supports theism. This dissertation seeks to determine just what exactly the logical implications of evolutionary theory are. Is evolution incompatible with theism? Does the acceptance of evolution necessarily entail naturalism and preclude theism? Is it possible, as naturalism maintains, that everything can be reduced to physical processes, or are there too many recalcitrant phenomena that defy reduction? Answering these involves a detailed analysis of the concepts, ‘evolution,’ ‘naturalism,’ and ‘theism.’ Just what exactly does accepting evolutionary theory entail? How is it different from Darwinism? Is evolution guided or unguided? What is naturalism? There are many different types of metaphysical naturalists: eliminative materialists, physicalists, and emergent property dualists. What is the relationship between metaphysical naturalism and methodological naturalism? Theism affirms a creator God who sustains all being, who is transcendent and yet immanent. So if theism posits a God who is active in the world, does this mean that scientific investigation may at times have to admit supernatural explanations when natural ones fail? My general conclusion is a type of mitigated skepticism – that given evolution, neither naturalism nor theism logically follows. As to whether evolution is guided or unguided, the only correct position is ‘undetermined.’ In this instance metaphysical positions may fill in the gaps in knowledge by projection, but cannot fulfill the necessary and sufficient conditions required for knowledge. Metaphysical naturalism and theism are worldviews that an individual adopts as the most overall coherent explanation of the wide variety of experiences, intuitions, and reflections on their life. Whether evolution offers evidence for one and against the other is often based upon one’s prior metaphysical assumptions, since all facts are theory laden. The underdetermination of theory allows for multiple theories to cover the same phenomena, with each offering an epistemically adequate explanation. However, numerous recalcitrant anomalies which defy scientific explanation and reduction present problems for the strict naturalist. While neither naturalism nor theism can be determined to be objectively true, one can offer reasons for choosing one or the other on the basis of overall coherence. (shrink)

We report the identification of a recurrent, 520-kb 16p12.1 microdeletion associated with childhood developmental delay. The microdeletion was detected in 20 of 11,873 cases compared with 2 of 8,540 controls and replicated in a second series of 22 of 9,254 cases compared with 6 of 6,299 controls. Most deletions were inherited, with carrier parents likely to manifest neuropsychiatric phenotypes compared to non-carrier parents. Probands were more likely to carry an additional large copy-number variant when compared to matched controls. The clinical (...) features of individuals with two mutations were distinct from and/or more severe than those of individuals carrying only the co-occurring mutation. Our data support a two-hit model in which the 16p12.1 microdeletion both predisposes to neuropsychiatric phenotypes as a single event and exacerbates neurodevelopmental phenotypes in association with other large deletions or duplications. Analysis of other microdeletions with variable expressivity indicates that this two-hit model might be more generally applicable to neuropsychiatric disease. © 2010 Nature America, Inc. All rights reserved. (shrink)

Pragmatism is a distinctive approach to clinical research ethics that can guide bioethicists and members of institutional review boards (IRBs) as they struggle to balance the competing values of promoting medical research and protecting human subjects participating in it. After defining our understanding of pragmatism in the setting of clinical research ethics, we show how a pragmatic approach can provide guidance not only for the day-to-day functioning of the IRB, but also for evaluation of policy standards, such as the one (...) that addresses acceptable risks for healthy children in clinical research trials. We also show how pragmatic considerations might influence the debate about the use of deception in clinical research. Finally, we show how a pragmatic approach, by regarding the promotion of human research and the protection of human subjects as equally important values, helps to break down the false dichotomy between science and ethics in clinical research. (shrink)

On the centennial of the death of William James (1842-1910), I approached faculty members at eighteen major theological centers of learning requesting them to identify the twelve most important books in the field of the psychology of religion written between James' 1902 classic The Varieties of Religious Experience up to Peter Homan's 1970 Theology After Freud. The request was for each faculty member (by agreement to remain anonymous) to identify the twelve books during that time period (1902-1970) which, in their (...) opinion, constituted major contributions to the development of the discipline of psychology of religion. By mutual agreement, James was credited with being the purported founder of the psychology of religion and Homans the quintessential culmination of the discipline's respectability. Though obviously subjective, the survey did register a consensus of scholars teaching in the field and what follows is a critical assessment of the merits of those books which they selected. (shrink)

At least since Descartes, philosophers have been interested in the special knowledge or authority that we exhibit when we speak about our own thoughts, attitudes, and feelings. This book contends that even the best work in contemporary philosophy of mind fails to account for this sort of knowledge or authority because it does not pay the right sort of attention to the notion of expression. What's at stake is not only how to understand self-knowledge and first-person authority, but also what (...) it is that distinguishes conscious from unconscious psychological states, what the mental life of a nonlinguistic animal has in common with our sort of mental life, and how to think about Wittgenstein's legacy to the philosophy of mind. (shrink)

We present a new understanding of Christ’s real presence in the Eucharist on the model of Stump’s account of God’s omnipresence and Green and Quan’s account of experiencing God in Scripture. On this understanding, Christ is derivatively, rather than fundamentally, located in the consecrated bread and wine, such that Christ is present to the believer through the consecrated bread and wine, thereby making available to the believer a second-person experience of Christ, where the consecrated bread and wine are the way (...) in which she shares attention with him. The consecrated bread and wine are then, in a sense, icons of Christ. (shrink)

I revise J L Mackie's first account of casual direction by replacing his notion of "fixity" by a newly defined notion of "sufficing" that is designed to accommodate indeterminism. Keeping Mackie's distinction between casual order and casual direction, I then consider another revision that replaces "fixity" with "one-way conditionship". In response to the charge that all such accounts of casual priority beg the question by making an unjustified appeal to temporal priority, i maintain that one-way conditionship explains rather that assumes (...) objective temporal dependence as well as objective casual dependence. (shrink)

Explanatory models in psychiatry reflect what clinicians deem valuable in rendering people's behavior intelligible and thus help guide treatment choices for mental illnesses. This article outlines some key scientific and ethical principles of clinical explanation in twenty-first century psychiatry. Recent work in philosophy of science, clinical psychiatry, and psychiatric ethics are critically reviewed in order to elucidate conceptual underpinnings of contemporary explanatory models. Many explanatory models in psychiatry are reductionistic or eclectic. The former restrict options for diagnostic and therapeutic paradigm (...) choice, while the latter lack a well-defined theoretical basis. These two methodological approaches stand in a dialectical relation to one another insofar as clinicians often move from one approach to its antithesis, ultimately seeking a synthesis of the two approaches that satisfies clinical needs. Pragmatic considerations can help to transcend the reductionism/eclecticism dialectic. In the absence of a completed science of mental disorders, psychiatrists must tolerate ambiguity and uncertainty as they strive to integrate diverse explanatory concepts in a rigorous and evidence-based fashion. A pragmatic explanatory model in clinical psychiatry must focus on favorable treatment outcomes for patients by respecting the pluralistic, participatory, and provisional nature of psychiatric explanation. (shrink)

Freud is often assumed to have given an explanation of how human beings acquire a morality, especially as it is manifested in the phenomenon of moral conscience. Freud himself certainly lends credence to such an interpretation of his theory, as the following passage testifies.

Critics of the conventional theory of biological evolution have asserted that while natural processes might result in some limited diversity, nothing fundamentally new can arise from “random” evolution. In response, biologists like Richard Dawkins have demonstrated that a computer program can generate a specific short phrase via evolution-like iterations starting with random gibberish. While such demonstrations are intriguing, they are flawed in that they have a fixed, prespecified future target, whereas in real biological evolution there is no fixed future target, (...) but only a complicated “fitness landscape.” In this study, a significantly more sophisticated evolutionary scheme is employed to produce text segments reminiscent of a Charles Dickens novel. The aggregate size of these segments is larger than the computer program and the input Dickens text, even when comparing compressed data. (shrink)

Hume, in "An Enquiry Concerning Human Understanding", holds (1) that all causal reasoning is based on experience and (2) that causal reasoning is based on nothing but experience. (1) does not imply (2), and Hume's good reasons for (1) are not good reasons for (2). This essay accepts (1) and argues against (2). A priori reasoning plays a role in causal inference. Familiar examples from Hume and from classroom examples of sudden disappearances and radical changes do not show otherwise. A (...) priori causal reasoning is closely related to understanding causal mechanisms. One uncovers the intelligibility of a causal process by understanding its mechanism. (shrink)

In "Causes and "If P, Even If X, still Q," Philosophy 57 (July 1982), Ted Honderich cites my "The Direction of Causation and the Direction of Conditionship," journal of Philosophy 73 (April 22, 1976) as an example of an account of causal priority that lacks the proper character. After emending Honderich's description of the proper character, I argue that my attempt to account for one-way causation in terms of one-way causal conditionship does not totally lack it. Rather than emphasize the (...) singularity of an effect, as Honderich does, I emphasize the multiplicity of independent factors in a causal circumstance. (shrink)

McTaggart argues that the A series, which orders events with reference to past, present, and future, involves an inescapable contradiction. The significant difference between the earlier version of his argument (Mind, 1908) and the version in The Nature of Existence, Volume II, Chapter 33 (1927), has often gone unnoticed. His arguments are all invalid; the conclusion can be rejected without rejecting any premiss. It is therefore unnecessary to adopt any philosophical thesis about time (e.g., that some token-reflexive analysis of tensed (...) statements is adequate) to avoid McTaggart's final conclusion that time is unreal. (shrink)

In this paper I discuss what triage is and how it might be applied to the preservation of endangered species. I compare the suggested application oftriage to endangered species with its application to wartime military practice, distribution of food aid, and human population control to show that the situation of endangered species is not analogous to these other suggested uses. I argue that, as far as species preservation is concemed, triage starts with the wrong norms and values: it is “human (...) chauvinistic,” giving primacy to economic, political, and sociocultural aspects that emphasize human interests without recognizing the connection between the survival of other species and the survival of humans. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Philosophy, Psychiatry, & Psychology 10.1 (2003) 53-55 [Access article in PDF] A Pragmatic Consideration of the Relation between Depression and Melancholia David H. Brendel THE MELANCHOLIA OF THE PAST and the major depression of the present are extraordinarily complex notions that represent different things to different people. With her compelling article "Is This Dame Melancholy? Equating Today's Depression and Past Melancholia," Jennifer Radden makes an important contribution to (...) the debate on whether these concepts are identical, overlapping, or distinct. Exploring both conditions from descriptive and causal points of view, Radden appropriately concludes that fully equating the two of them would constitute a "troubling oversimplification." Her line of reasoning runs as follows. Because past descriptions of melancholia and current descriptions of major depression are marked by dissimilarities (such as the genius and creativity associated with the former and the self-loathing and emphasis on loss associated with the latter), only an underlying causal base common to both conditions would justify our equating them. But the cause (or causes) of melancholia and depression remain mysterious. Thus, although Radden acknowledges that a causal explanation might yield substantial benefits ("research possibilities, further hypotheses, and even hope of prevention, or cure"), she suggests that we remain in a descriptive mode when comparing the two conditions and conclude that they are not one and the same.Radden's argument that past melancholia and contemporary depression are descriptively distinct is convincing and, I think, indisputable. But I would like to challenge and expand upon some of her ideas about considerations of causality and about the role of pragmatic reasoning in working out the relation between melancholia and depression. First of all, although Radden is correct that the cause of many (or perhaps most) depressive states is unknown, she underrates the extent of the empirical knowledge that we have acquired about the causation of depression and, in so doing, undervalues the relevance of causal reasoning to making the melancholia/depression distinction. Recent empirical research has revealed that major depressive episodes can result from brain lesions such as left-sided strokes or metabolic disorders such as hypothyroidism (Yudofsky and Hales 2002). Psychosocial research, moreover, has suggested that stressful life events also can be understood as causes of depression (Kendler, [End Page 53] Karkowski, and Prescott 1999). These findings provide some hope that the identification of causes of various clinical states is a real possibility. Identification of such causes, I believe, could empower us to make some plausible claims about the similarities or differences between past melancholia and current depression. A melancholic individual like van Gogh, for example, had a different illness than a contemporary stroke patient with major depression in a present-day hospital, not only on the basis of descriptive distinctions between their conditions, but also on the basis of the causes of their respective states. Although of course we cannot know the cause of van Gogh's melancholia, we can reasonably assume that it was not the result of a left-sided stroke due to the absence in his case of other clinical deficits that usually result from such a stroke (such as language and motor deficits). Plausible assertions about the causes of melancholic and depressive states would add to the robustness of any claims regarding the distinctness of the conditions.Conversely, careful consideration of the etiology of various clinical presentations might prompt us to hypothesize a shared pathophysiology and thereby lead us to believe that they are essentially identical conditions. It is difficult or impossible to discover a cause of melancholia in individuals who lived in past eras. But we might achieve our goal by comparing well-defined major depression to various forms of what Radden calls "masked depression," such as those seen in cross-cultural settings, where the subjective symptoms of sad mood are absent but numerous somatic signs of depression are observed. If it turned out that major depression and masked depression had the same cause, then differences in their clinical phenomenology would become merely surface differences that belie a shared etiological process. How might one discover the existence of such a process... (shrink)

This new edition includes three new chapters, updating the book to take into account developments in the field over the past fifteen years.

For a stable visual world, the colours of objects should appear the same under different lights. This property of colour constancy has been assumed to be fundamental to vision, and many experimental attempts have been made to quantify it. I contend here, however, that the usual methods of measurement are either too coarse or concentrate not on colour constancy itself, but on other, complementary aspects of scene perception. Whether colour constancy exists other than in nominal terms remains unclear.

We present a set of algorithms for automated simplification of symbolic constants of the form ∑iαixi with αi rational and xi complex. The included algorithms, called SimplifySum2 and implemented in Mathematica, remove redundant terms, attempt to make terms and the full expression real, and remove terms using repeated application of the multipair PSLQ integer relation detection algorithm. Also included are facilities for making substitutions according to user-specified identities. We illustrate this toolset by giving some real-world examples of its usage, including (...) one, for instance, where the tool reduced a symbolic expression of approximately 100 000 characters in size enough to enable manual manipulation to one with just four simple terms.2Available from https://github.com/alexkaiser/SimplifySum. (shrink)

Erdelyi's dialectical repression theory attempts to reconcile what appear to be incompatible perspectives in the contentious area of memory for trauma. He partially succeeds and makes a strong case that repression is “an empirical fact,” but makes a weaker case that distortions and omissions are due to the same mechanism and that recovered memories are necessarily unreliable. Available data do not suggest that the return of the repressed is any less accurate than the return of the non-repressed.

Ex nihilo nihil fit: PHILOSOPHY'S "STARTING POINT" Periodically, philosophers have had the feeling that somehow the entire weight of the traditional ...

Naive mereology studies ordinary, common-sense beliefs about part and whole. Some of the speculations in this article on naive mereology do not bear directly on Peter van Inwagen's "Material Beings". The other topics, (1) and (2), both do. (1) Here is an example of Peter Unger's "Problem of the Many". How can a table be a collection of atoms when many collections of atoms have equally strong claims to be that table? Van Inwagen invokes fuzzy sets to solve this problem. (...) I claim that an alternative treatment of vagueness, supervaluations over many-value valuations, provides a better solution. (2) The Special Composition Question asks how parts compose a whole. One who rejects van Inwagen's answer in terms of constituting a life need not provide some alternative answer. Even if all answers to the Special Question fail, there are a multitude of less general composition questions that are not so difficult. (shrink)

A primary purpose of argument is to increase the degree of reasonable confidence that one has in the truth of the conclusion. A question begging argument fails this purpose because it violates what W. E. Johnson called an epistemic condition of inference. Although an argument of the sort characterized by Robert Hoffman in his response (Analysis 32.2, Dec 71) to Richard Robinson (Analysis 31.4, March 71) begs the question in all circumstances, we usually understand the charge that an argument is (...) question begging with reference to the beliefs of the person, or the sort of person, to whom the argument is directed. (shrink)

In the form of inference known as inference to the best explanation there are various ways to characterise what is meant by the best explanation. This paper considers a number of such characterisations including several based on confirmation measures and several based on coherence measures. The goal is to find a measure which adequately captures what is meant by 'best' and which also yields the truth with a high degree of probability. Computer simulations are used to show that the overlap (...) coherence measure achieves this goal, enabling the true explanation to be identified almost as often as an approach which simply selects the most probable explanation. Further advantages to this approach are also considered in the case where there is uncertainty in the prior probability distribution. (shrink)

We present a conceptual framework on the experience of time and provide a coherent basis on which to base further inquiries into qualitative approaches concerning time experience. We propose two Time-Layers and two Time-Formats forming four Time-Domains. Micro-Flow and Micro-Structure represent the implicit phenomenal basis, from which the explicit experiences of Macro-Flow and Macro-Structure emerge. Complementary to this theoretical proposal, we present empirical results from qualitative content analysis obtained from 25 healthy participants. The data essentially corroborate the theoretical proposal. With (...) respect to Flow, the phenomenally accessible time experience appeared as a continuous passage reaching from the past through the present into the future. With respect to Structure, the individual present was embedded in the individual biography, emerging from past experiences and comprising individual plans and goals. New or changing plans and goals were being integrated into the existing present, thus forming a new present. The future appeared as changeable within the present, by means from the past, and therefore as a space of potential opportunities. Exemplarily, we discuss these results in relation to previous empirical findings on deviant experiences of time in Autism Spectrum Disorder that is presumably characterized by a breakdown of Flow and concomitant compensatory repetition resulting in an overly structured time. Finally, we speculate about possible implications of these findings both for psychopathological and neuroscientific research. (shrink)